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Plos One : Old-growth Platycladus Orientalis as a Resource for Rep...

By: Giovanni G. Vendramin

Description : The old-growth artificial populations of P. orientalis have significantly higher genetic diversity than younger artificial populations and similar levels to those in extant natural populations. The imperial parks and ancient temples, which have protected these old-growth trees for centuries, have played an important role in maintaining the genetic diversity and reproductive capacity of this tree species.

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Plos One : Regulation of Cox2 Expression in Mouse Mammary Tumor Ce...

By: Yi Li

Description : Due to the systemic effects of COX2 inhibitors, we propose targeting specific EP receptors as therapeutic interventions to breast cancer progression.

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Plos One : Cisplatin-induced Apoptosis Inhibits Autophagy, Which A...

By: Irina V. Lebedeva

Description : The interplay between a non-lethal autophagic response and apoptotic cell death is still a matter of debate in cancer cell biology. In the present study performed on human melanoma cells, we investigate the role of basal or stimulated autophagy in cisplatin-induced cytotoxicity, as well as the contribution of cisplatin-induced activation of caspases 3/7 and conventional calpains. The results show that, while down-regulating Beclin-1, Atg14 and LC3-II, cispl...

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Plos One : Effects of Acute Exposure to Moderate Altitude on Vascu...

By: Shengxu Li

Description : Short-term stay at moderate altitude is associated with increased blood pressure and heart rate likely due to augmented sympathetic activity. Exposure to moderate altitude improves the lipid profile and systemic inflammation, but seems to have no significant effect on glucose metabolism.

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Plos One : How Does Emotional Context Modulate Response Inhibition...

By: Marianna Mazza

Description : These findings suggest that difficulties in identifying feelings, particularly in negative emotions, is a major feature of alexithymia, and the ACC plays a critical role in emotion-modulated response inhibition related to alexithymia.

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Plos One : Osteopontin Level in Synovial Fluid is Associated with ...

By: Joel Joseph Gagnier

Description : Our data suggest that OPN Full and N-half have distinct functions in articular cartilage homeostasis and in human joint pain.

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Plos One : Conservation Implications of Changes in Endemic Hawaiia...

By: Patrick O’grady

Description : Endemic Hawaiian Drosophilidae, a radiation of nearly 1000 species including 13 federally listed as endangered, occur mostly in intact native forest, 500–1500 m above sea level. But their persistence in disturbed forest and agricultural areas has not been documented. Thus, control efforts for agricultural pests may impact endemic species if previously undocumented refugia in agricultural areas may play a role in their conservation. To quantify whether invas...

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Plos One : Tumor Necrosis Factor Alpha Rs1800629 Polymorphism and ...

By: Rui Medeiros

Description : The meta-analysis suggests that TNF-a rs1800629 polymorphism is associated with increased risk of cervical lesions, especially in Caucasians.

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Plos One : Sites of Glucose Transporter-4 Vesicle Fusion with the ...

By: Julie G. Donaldson

Description : In adipocytes, vesicles containing glucose transporter-4 (GLUT4) redistribute from intracellular stores to the cell periphery in response to insulin stimulation. Vesicles then fuse with the plasma membrane, facilitating glucose transport into the cell. To gain insight into the details of microtubule involvement, we examined the spatial organization and dynamics of microtubules in relation to GLUT4 vesicle trafficking in living 3T3-L1 adipocytes using total ...

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Plos One : Enhanced Vitellogenesis in a Whitefly Via Feeding on a ...

By: Immo A. Hansen

Description : Background : The MEAM1 (B biotype) Bemisia tabaci (Gennadius) is one of the most widespread and damaging whitefly cryptic species. Our previous studies discovered that the MEAM1 whitefly indirectly benefits from interactions with the tomato yellow leaf curl China virus (TYLCCNV) via accelerated ovarian development and increased fecundity. However, the physiological mechanism of begomoviruse-infected plants acting on the reproduction of the insect vector was...

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Plos One : Poly-ub-substrate-degradative Activity of 26S Proteasom...

By: Javier Vitorica

Description : Proteostasis is critical for the maintenance of life. In neuronal cells an imbalance between protein synthesis and degradation is thought to be involved in the pathogenesis of neurodegenerative diseases during aging. Partly, this seems to be due to a decrease in the activity of the ubiquitin-proteasome system, wherein the 20S/26S proteasome complexes catalyse the proteolytic step. We have characterised 20S and 26S proteasomes from cerebrum, cerebellum and h...

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Plos One : Structure Determination and Biochemical Characterizatio...

By: Alexander Wlodawer

Description : The crystal structure of a putative HNH endonuclease, Gmet_0936 protein from Geobacter metallireducens GS-15, has been determined at 2.6 A° resolution using single-wavelength anomalous dispersion method. The structure contains a twostranded anti-parallel b-sheet that are surrounded by two helices on each face, and reveals a Zn ion bound in each monomer, coordinated by residues Cys38, Cys41, Cys73, and Cys76, which likely plays an important structural role i...

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Plos One : Creation of an Open-access, Mutation-defined Fibroblast...

By: Cesar V. Borlongan

Description : Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and t...

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Plos One : Inhibiting Delta-6 Desaturase Activity Suppresses Tumor...

By: Wolf-hagen Schunck

Description : Recent studies have shown that a tumor-supportive microenvironment is characterized by high levels of pro-inflammatory and pro-angiogenic eicosanoids derived from omega-6 (n26) arachidonic acid (AA). Although the metabolic pathways (COX, LOX, and P450) that generate these n26 AA eicosanoids have been targeted, the role of endogenous AA production in tumorigenesis remains unexplored. Delta-6 desaturase (D6D) is the rate-limiting enzyme responsible for the sy...

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Plos One : Direct Angiotensin II Type 2 Receptor Stimulation Ameli...

By: Haiyan Xu

Description : The present study demonstrated that direct AT2 receptor stimulation by C21 accompanied with PPARc activation ameliorated insulin resistance in T2DM mice, at least partially due to improvement of adipocyte dysfunction and protection of pancreatic b cells.

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Plos One : Successful Human Infection with P. Falciparum Using Thr...

By: Aric Gregson

Description : Controlled human malaria infection (CHMI) is a powerful method for assessing the efficacy of anti-malaria vaccines and drugs targeting pre-erythrocytic and erythrocytic stages of the parasite. CHMI has heretofore required the bites of 5 Plasmodium falciparum (Pf) sporozoite (SPZ)-infected mosquitoes to reliably induce Pf malaria. We reported that CHMI using the bites of 3 PfSPZ-infected mosquitoes reared aseptically in compliance with current good manufactu...

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Plos One : Efficient Arsenic Metabolism — the as3Mt Haplotype is A...

By: Brock C. Christensen

Description : Arsenic is a very potent toxicant. One major susceptibility factor for arsenic-related toxicity is the efficiency of arsenic metabolism. The efficiency, in turn, is associated with non-coding single nucleotide polymorphisms (SNPs) in the arsenic methyltransferase AS3MT on chromosome 10q24. However, the mechanism of action for these SNPs is not yet clarified. Here, we assessed the influence of genetic variation in AS3MT on DNA methylation and gene expression...

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Plos One : Two Distinct Categories of Focal Deletions in Cancer Ge...

By: William B. Coleman

Description : One of the key questions about genomic alterations in cancer is whether they are functional in the sense of contributing to the selective advantage of tumor cells. The frequency with which an alteration occurs might reflect its ability to increase cancer cell growth, or alternatively, enhanced instability of a locus may increase the frequency with which it is found to be aberrant in tumors, regardless of oncogenic impact. Here we’ve addressed this on a geno...

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Plos One : Engineering Pseudomonas Protegens Pf-5 for Nitrogen Fix...

By: Marie-joelle Virolle

Description : Nitrogen is the second most critical factor for crop production after water. In this study, the beneficial rhizobacterium Pseudomonas protegens Pf-5 was genetically modified to fix nitrogen using the genes encoding the nitrogenase of Pseudomonas stutzeri A1501 via the X940 cosmid. Pf-5 X940 was able to grow in L medium without nitrogen, displayed high nitrogenase activity and released significant quantities of ammonium to the medium. Pf-5 X940 also showed c...

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Plos One : Alternative Transcripts and 39Utr Elements Govern the I...

By: Georg Stoecklin

Description : Selenoprotein S (SelS) is a 189 amino acid trans-membrane protein that plays an important yet undefined role in the unfolded protein response. It has been proposed that SelS may function as a reductase, with the penultimate selenocysteine (Sec188) residue participating in a selenosulfide bond with cysteine (Cys174). Cotranslational incorporation of Sec into SelS depends on the recoding of the UGA codon, which requires a Selenocysteine Insertion Sequence (SE...

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