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World Health Organization : Year 1991, World Health Organization, Hereditary Disease Program Icbdms Icbd, No. 91.4.1: Report of a Joint WBO/ICBDNS/ICBD Meeting on Methodology for Birth Defects Monitoring

By World Health Organization

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Book Id: WPLBN0000003533
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Reproduction Date: 2005
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Title: World Health Organization : Year 1991, World Health Organization, Hereditary Disease Program Icbdms Icbd, No. 91.4.1: Report of a Joint WBO/ICBDNS/ICBD Meeting on Methodology for Birth Defects Monitoring  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Organization, W. H. (n.d.). World Health Organization : Year 1991, World Health Organization, Hereditary Disease Program Icbdms Icbd, No. 91.4.1. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
In this report, presentations and discussions on multiple congenital anomalies (MCA) from the collaborative WHO/ICBDMS meeting on methodology for birth defects monitoring, held in Sydney, Australia, from 6-7 September 1991, are summarized.

Table of Contents
List of Contem 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 2 . BIOLOGICAL ASPECTS OF MULTIPLE CONGENITAL ANOMALIES . . . . . . . . . . . . . . . . 3 2 . 1 Syndromes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2 . 2 S e q u e n c e s . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2 . 3 A d d i t i v e p a t t e r n s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2 . 4 C l i n i c a l l y r e c o g n i z e d p h e n o t y p e s . . . . . . . . . . . . . . . . . . . . . . 4 2.5 N e w p h e n o t y p e s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.6 Chance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . b 3 . NETHODO'LOGICAL ASPECTS OF MULTXPLE CONGENITAL ANOMALIES . . . . . . . . . . . . . . 4 3 V a r i a b i l i t y o f a s c e r t a i n m e n t of m u l t i p l e c o n g e n i t a l a n o m a l i e s . . . . . . . . L 3 . 2 M e t h o d o l o g i c a l i s s u e s o f lumping a n d s p l i t t i n g on t h e b a s i s o f a s s o c i a t e d c o n g e n i t a l a n o m a l i e s . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.3 The r o l e of c l i n i c a l dysmorphology i n c l a s s i f i c a t i o n . . . . . . . . . . . . 5 3 . 3 . 1 S p l i t t i n g i s o l a t e d d e f e c t s . . . . . . . . . . . . . . . . . . . . . . 6 3 . 3 . 2 Lumping i s o l a t e d d e f e c t s . . . . . . . . . . . . . . . . . . . . . . . 7 3 . 3 . 3 S p l i t t i n g and lmping m u l t i p l e c o n g e n i t a l a n o m a l i e s . . . 7 4 . STATISTICAL ASPECTS OF WLTIPLE CONGENITAL ANOMALIES . . . . . . . . . . . . . . . 7 4 . 1 Do defects c l u s t e r t o g e t h e r more than by c h a n c e a l o n e ? . . . . . . . . . . . 7 4 . 2 Is there s p e c i f i c c l u s t e r i n g o f birth d e f e c t s ? . . . . . . . . . . . . . . . 7 b . 3 C l u s t e r a n a l y s i s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 4 . 3 . 1 H i e r a r c h i c a l c l u s t e r i n g . . . . . . . . . . . . . . . . . . . . . . . . . 8 4 . 3 . 2 Block c l u s t e r i n g . . . . . . . . . . . . . . . . . . . . . . . . . . 9 5 . PRACTICAL ASPECTS OF H'ULTIPLE CONGENITAL ANOMALIES IN AN ICBDMS SURVEILLANCE SYSTEM . . . . . . . . . . . . . . . . . . . . . . . . . .

 

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