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European Occupational Health Series : World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe; Icp, Infection Prevention and Control Ath 004 11, (Icp, Infection Prevention and Control Lab 006): Functions of Hospital Laboratories as Related to Public Health Bacteriology

By Ingegerd Moberg, Dr.

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Book Id: WPLBN0000033668
Format Type: PDF eBook
File Size: 0.1 MB
Reproduction Date: 2005

Title: European Occupational Health Series : World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe; Icp, Infection Prevention and Control Ath 004 11, (Icp, Infection Prevention and Control Lab 006): Functions of Hospital Laboratories as Related to Public Health Bacteriology  
Author: Ingegerd Moberg, Dr.
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
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Publisher: World Health Organization

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Dr, I. M. (n.d.). European Occupational Health Series : World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe; Icp, Infection Prevention and Control Ath 004 11, (Icp, Infection Prevention and Control Lab 006). Retrieved from http://hawaiilibrary.net/


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Medical Reference Publication

Excerpt
INTRODUCTION The practice of early prenatal diagnosis by chorionic villus sampling (CVS) has opened the first trimester of pregnancy to medical and scientific investigation. When CVS was first introduced, the World Health Organization (WHO) Hereditary Diseases Programme identified its potential importance, noted that the technique was more complex than it seemed and that success depends on the quality of the team, and recommended collaborative monitoring and assessment from the outset (1,2). An informal WHO-sponsored Registry was established in Philadelphia (USA), which regularly circulated CVS Latest News. Several randomised studies comparing CVS with amniocentesis, and later comparing transabdominal with transcervical CVS, were also undertaken. Recent reports of a few clusters of children born with limb anomalies after CVS make it necessary to re-examine existing collected data and the results of randomised studies. The European Regional Office of the WHO (WHO/EURO) organized the present meeting in association with the VIth International Conference on Early Prenatal Diagnosis of Genetic Diseases, to involve centres with the largest experience of CVS in the review and critical assessment of its safety and accuracy a decade after it was introduced into clinical practice. The objective was to produce an expert statement regarding the use of CVS in prenatal diagnosis. 2. COLLECTED EXPERIENCE OF CVS The informal CVS Register includes over 80,000 cases reported up to May 1992, but it is estimated that less than half the procedures done are reported to the Newsletter. Global experience of CVS can be safely assumed to exceed 150,000 cases. The Register focuses on the fetal loss rate following the procedure, among cytogenetically normal pregnancies intended to continue. This has on an average been about 48, ranging from 2 to 7% at individual centres. The fetal loss rate is in general lowest at centres with the largest experience. The Registern data thus shows the order of loss associated with good practice, and also gives clear evidence of considerable inter-centre variation. Table 1 shows fetal loss rate and limb reduction defects in 25 centres reporting 700 and more cases, based on the latest CVS Newsletter (Jackson, this Conference).

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