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World Health Organization : Technical Report Series, No. 386: Hormonal Steroids It Cohtraception

By World Health Organization

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Book Id: WPLBN0000049200
Format Type: PDF eBook
File Size: 1.2 MB
Reproduction Date: 2005
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Title: World Health Organization : Technical Report Series, No. 386: Hormonal Steroids It Cohtraception  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

Citation

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Organization, W. H. (n.d.). World Health Organization : Technical Report Series, No. 386. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
1. INTRODUCTION In 1964 a WHO Scientific Group on the Mechanism of Action of Sex Hormones and Analogous Substances 1 reviewed what was then known of all the sex hormones, including steroid drugs used for contraception. In the following year, another WHO Scientific Group examined the basic and clinical aspects of oral gestogens; after reviewing the report of this Group, the WHO Advisory Committee on Medical Research recommended that the Organization periodically evaluate developments in, and clinical experience with, contraceptives. The primary objectives of the present meeting were to review the extensive information that had become available since the meeting of the 1965 Scientific Group and to define areas that are of continuing concern and that require further study. Thus, the two reports are complementary and should be read in conjunction.3

Table of Contents
CONTENTS 1. Introduction . . . . . . . . . . . . . . . . . . . . 5 2 . Combined and sequential oestrogenic. 'progestogenic pro- ducts for oral contraception . . . . . . . . . . . . . 6 2.1 New drugs. regimens. and dosages . . . . . . . . 6 2.2 Mode of action . . . . . . . . . . . . . . . . . 6 2.3 Contraceptive effectiveness in clinical practice . . . . 8 2.4 Other effects of possible clinical significance . . . . 9 2.5 Tndications and contraindications . . . . . . . . 18 2.6 Extent of use . . . . . . . . . . . . . . . . . . 19 3 . Other hormonal contraceptive formulations . . . . . . 21 3.1 Oral progestogens alone . . . . . . . . . . . . . 21 3.2 Oestrogens alone . . . . . . . . . . . . . . . . 22 3.3 Long-acting oral fornlulations . . . . . . . . . . 22 3.4 Long-acting injectable for~nulations . . . . . . . . 22 4 . Guidelines for the use and study of steroid contraceptives . 23 4.1 Clinical management . . . . . . . . . . . . . . 23 4.2 Preclinical studies . . . . . . . . . . . . . . . . 23 4.3 Clinical trials . . . . . . . . . . . . . . . . . . 24 4.4 Epidemiological surveillance . . . . . . . . . . . 24 5 . Recommendations . . . . . . . . . . . . . . . . . . 24 Annex . Currently marketed oral contraceptives . . . . . . 27

 

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