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World Health Organization : (Emro) Regional Office for the Eastern Mediterranean, Year 1994-99 ; World Health Organization-Eastern Mediterranean : Communicable Diseases and Emerging Infectious Diseases, No. 45 E L: Consultation on the Involvement of the Private Sector in Surveillances of Communicable Diseases

By World Health Organization

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Book Id: WPLBN0000078118
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title: World Health Organization : (Emro) Regional Office for the Eastern Mediterranean, Year 1994-99 ; World Health Organization-Eastern Mediterranean : Communicable Diseases and Emerging Infectious Diseases, No. 45 E L: Consultation on the Involvement of the Private Sector in Surveillances of Communicable Diseases  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Organization, W. H. (n.d.). World Health Organization : (Emro) Regional Office for the Eastern Mediterranean, Year 1994-99 ; World Health Organization-Eastern Mediterranean : Communicable Diseases and Emerging Infectious Diseases, No. 45 E L. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
Clinicians baize long suspected a relationship between malaria and nephritis in Africa. The results of tests made several years ago suggested that the relationship might be an immrinological one. This memorandunt discusses clinical, epidemiological, morpholo~ical, and immunopathological aspects of malaria-associated nephropall~y, u,ill special emphosis on immunalo~ical investiaations. Immunofluorescence studies on renal - - bioosies ,+om patients with the nephrotic syndrome and Plasmodium malariae parasitaemia have shofi,~? the presence of immunoglobulrn (Ig) depos~rs with certain con~plemenf components oil glonlerular basement membrane.^. IgG with anti-P. malariae specificity has been fowd in eluates of kidney tissue Jrom such patients and P. malariae antigen was identified in Ihe glomerular basenlent membrane by immunofluorescence studies. These observations support the view that the irephropathy associated with P. malariae infections is a form of immrrrre complex nephritis lnitiared by circulating P. malariae antigens and anti-P. malariae antibodies. Additional sripport is obfainedfrom electron microscope studies, which show that electron-dense material is associated with the glomerular basement membrane in certain diseases of the kidney in which immune complexes hare been detected in glomeruli by immunofiorescence methods. The view that rrralarial nephritis is a form of immune complex disease should be roeful in stirnularing new approacl~s to the study of the pathogenesis of both the initiating and the perpetrialing immunoparlwlogical lesion.

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