World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

World Health Organization : Year 1993 ; World Health Organization, Programme on Chemical Safety, No. 93.34, (Pirimiphos): Pirimiphos-Methyl

By D. J. Clegg

Click here to view

Book Id: WPLBN0000108334
Format Type: PDF eBook
File Size: 1.6 MB
Reproduction Date: 2005
Full Text

Title: World Health Organization : Year 1993 ; World Health Organization, Programme on Chemical Safety, No. 93.34, (Pirimiphos): Pirimiphos-Methyl  
Author: D. J. Clegg
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

Citation

APA MLA Chicago

Clegg, D. J. (n.d.). World Health Organization : Year 1993 ; World Health Organization, Programme on Chemical Safety, No. 93.34, (Pirimiphos). Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
Oral administration of 0.6 mg 2-14C-ring labelled pirimiphos-methyllkg bw to 5 male rats resulted in a mean urinary excretion of 80.7% and mean faecal excretion of 7.3% in 24 h, indicating rapid absorption. At 96 h, 86.0% and 15.2% of the administered dose had been excreted in urine and faeces, respectively. Nine metabolites (unidentified) were present in the urine (Bratt & Dudley, 1970). Female rats given 7.5 mg 2-14c pirimiphos-methyl/kg bw orally were bled (cardiac puncture, 3 rats per time interval) at 0.5, 1, 3, 5, 7 or 24 h post-dosing. Maximum blood levels (at 0.5 h) were 2-3 pg/ml, declining by 50% 1 h postdosing. By 24 h, levels of 14c in blood were 0.2 to 0.3 pg/ml, and of pirimiphosmethyl, 0.01-0.02 pg/ml. Rats treated for 4 days at 7.5 mg 2-14c pirimiphosmethyllkg bw/day and sacrificed at 24 h intervals did not show any increase in blood levels with time. Tissue levels of total radioactivity in liver, kidney and fat over the 4 day period were generally below 2 mg pirimiphos-methyl equivalentslkg tissue (levels of unchanged pirimiphos-methyl being less than 0.15 mg/kg tissue). There was no evidence of tissue accumulation (Mills, 1976).

Table of Contents
NA

 

Click To View

Additional Books


  • Bulletin of the World Health Organizatio... (by )
  • World Health Organization : Organisation... (by )
  • World Health Organization : Organisation... (by )
  • World Health Organization : Report on a ... (by )
  • World Health Organization : Year 1996 ; ... (by )
  • World Health Organization : Year 1999 ; ... (by )
  • Bulletin of the World Health Organizatio... (by )
  • Bulletin of the World Health Organizatio... (by )
  • European Occupational Health Series : Ye... (by )
  • World Health Organization Publication : ... (by )
  • World Health Organization : Technical Re... (by )
  • World Health Organization, Weekly Epidem... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.