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Bulletin of the World Health Organization : 1994; Volume 72, Number 3, Year 1994 72 (3), Pages 401-408: Are Childhood Immunization Programs in Australia at Risk? Investigation of the Cold Chain in the Northern Territory

By N. C. Miller

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Book Id: WPLBN0000121554
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title: Bulletin of the World Health Organization : 1994; Volume 72, Number 3, Year 1994 72 (3), Pages 401-408: Are Childhood Immunization Programs in Australia at Risk? Investigation of the Cold Chain in the Northern Territory  
Author: N. C. Miller
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Miller, N. C. (n.d.). Bulletin of the World Health Organization : 1994; Volume 72, Number 3, Year 1994 72 (3), Pages 401-408. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
Live influenza virus vaccinorion has potential advantages and disadvantages compared with killed virus vaccine given b . ~in tramuscular injection. Attempts have been made to achie~,ec omplete attenuation ofinj'luenza A2 and B strains bv up to 30 serialpassages in the allanroic cavity of eggs at 33°C. No attenuation occurred. The method of passing viruses in the presence of an increasing concentration of horse serum, thus selecting inhibitor-resistant variants, has also been tested. It was shown that serial passage induced an increasing degree of inhibitor resistance in tlre virus and an increasing degree of atten~ration when rested in volunteers. This was observed with both an Asian strain and o Hong Kong srroin. The Hong Kong virus was also passed serially ot 25'C in eggs but did not seem much further attenuated as a result; however, a virus strain supplied by H. F. Maassab with a much higher degree of adaptation to low temperature is being tested. Portly or completely attenuated strains hape been used to induce or detect protection. lnfienza B strains gave portial protection affe~ I dose and almost complete protection ajier 2 doses and protection persisted for 7 months. A comparative study showed that there was protection afler ~acrinationw ith killed virus by the parenteral route, and with live virus by the nosol rorrre.

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