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European Occupational Health Series : 1998-99; Prevention in Primary Care, Dlvr 04 01 01-In German: En Rahmen Fur Die Fachiche UND Administrative Weiterntwicklung Der Hausarztlichen Versorgung Auf Allgemeinmedizinischer Grundlage in Europa

By World Health Organization

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Book Id: WPLBN0000139884
Format Type: PDF eBook
File Size: 0.9 MB
Reproduction Date: 2005

Title: European Occupational Health Series : 1998-99; Prevention in Primary Care, Dlvr 04 01 01-In German: En Rahmen Fur Die Fachiche UND Administrative Weiterntwicklung Der Hausarztlichen Versorgung Auf Allgemeinmedizinischer Grundlage in Europa  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
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Publisher: World Health Organization

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Organization, W. H. (n.d.). European Occupational Health Series : 1998-99; Prevention in Primary Care, Dlvr 04 01 01-In German. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
Mefloquine is an effective treatment for multidrugresistant malaria (1-5); however, despite its wides~ readus e in Thailand since 1984 there are a number of aspects of its pharmacokinetics that are poorly understood. Looareesuwan et al. have shown that the pedk mefloquinc c.>ncentrationh tn Thm patrnts uith acute F~lc~parumml laria uho reccived a 250-mg Jose were dpprdx~mateltjh ree times hidhcr than in healthy Caucasian v~~luntcerasl;s o, ihc apparent \olumr of distribution nas smallcr and the terminal half-Ilk was significantly shorter in the Thai patients (6). However, it was not ~ossibleto determine whether ethnic or disease-related factors were responsible for these differences. Recently Karbwang et al. studied the kinetics of a single oral dose of mefloquine (750 mg) in Thai patients with falciparum malaria and compared the results with those of a ~reviousst udvinvolvine healthv Thai volunteers (7,8)..~or patientsand controls the; were no significant differences in the wak ~lasma concentrations ofmefloquine, time to peak conkntration, area under the concentration-time curve, or apparent volume of distribution; however, the terminal half-life was significantly shorter in the patients.

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