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World Health Organization Fact Sheet, Year 2006, Volume 298: World Health Organization Fact Sheet

By World Health Organization

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Book Id: WPLBN0000170753
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title: World Health Organization Fact Sheet, Year 2006, Volume 298: World Health Organization Fact Sheet  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

Citation

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Organization, W. H. (n.d.). World Health Organization Fact Sheet, Year 2006, Volume 298. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
Ehrlich put forward the idea that the objective of chemical ,attack upon noxious micro-organisms should be to interfere with the metabolic processes of the parasite in a specific manner, so that the host itself be uninjured. At the time Ehrlich proposed this, however, relatively little was known about those metabolic processes n-hich could be injured or about how they could be injured. The result v7as that, even with this guiding principle, there was little opportunity to applj- it in practice, except indirectly and empirically. For instance, Ehrlich chose the objective of designing organometallic compounds whereby a substance such as arsenious oxide, already known to possess toxic properties for some biological forms, should be incorporated as part: of more or less complex carbon compounds, so that the general toxic activity might be modified and made more specific. The various chemical structures n-ere designed in a more or less empirical manner, based on the possibilities of organic chemistry rather than on an assumed or known mode of action defined in terms of cell-physiology. Modifications of structure Ivere guided by the results of biological tests of inhibitory effectiveness and e~mtually by clinical trial. Thus the main practical result of Ehrlich's ideas in the guidance of research was related chiefly to the enhancement of specificity, guided by biological tests, when a lead as to toxicity had been obtained.

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