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Bulletin of the World Health Organization : 1962; Volume 26, Number 5, Year 1962, Pages 619-631: Leukaemia in Nagasaki Atomic Bomb Survivors from 1945 through 1959

By Masanobu Tomonaga

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Book Id: WPLBN0000177218
Format Type: PDF eBook
File Size: 0.8 MB
Reproduction Date: 2005

Title: Bulletin of the World Health Organization : 1962; Volume 26, Number 5, Year 1962, Pages 619-631: Leukaemia in Nagasaki Atomic Bomb Survivors from 1945 through 1959  
Author: Masanobu Tomonaga
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Tomonaga, M. (n.d.). Bulletin of the World Health Organization : 1962; Volume 26, Number 5, Year 1962, Pages 619-631. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
Particles of influenzavirus contain two different virus-coded surface antigens, the haemagglutinin - and the enzyme neuraminidase. These antigens reside in different protein suhunits and antigenic variation (antigenic drift and major antigenic shifts) occurs in both suhunits. Antigenic drift, which involves gradual changes .in the surface antigens of influenzavirus, is thought to result from the selection, in an immune host population, of mutant virus particles that have altered antigenic determinants and that therefore possess a growth advantage in the presence of antibody. It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in the amino acid sequence in the polypeptides of the haemagglutinin suhunits and it is likely that antigenic drift in the neuraminidase occurs by the same mechanisms. The other kind of antigenic variation (major antigenic shifts) involves sudden and complete changes in one or both of the surface antigens so that new viruses arise to which the population has little or no immunity and it is these viruses

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