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World Health Organization Publication : Year 2004 ; Issue 924166519X, Pages Araquat: Paraquat

By World Health Organization

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Book Id: WPLBN0000189858
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005
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Title: World Health Organization Publication : Year 2004 ; Issue 924166519X, Pages Araquat: Paraquat  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Organization, W. H. (n.d.). World Health Organization Publication : Year 2004 ; Issue 924166519X, Pages Araquat. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
Paraquat is a bipyridilium herbicide that was evaluated by the JMPR in 1970, 1972, 1976, 1985 and 1986 (Annex 1, references 14, 18, 26, 47), in order to establish an acceptable daily intake (ADI). A toxicological monograph was published after the 1970 JMPR and addenda to the monograph were published after the 1972, 1976 and 1982 Meetings. A toxicological monograph was published after the 1986 JMPR. At the JMPR in 1970, an ADI of 0–0.001mg/kgbw, as paraquat dichloride, was established. The 1972 JMPR assigned an ADI of 0–0.002mg/kgbw, while the 1982 JMPR reduced the ADI to 0–0.001mg/kgbw. The 1986 JMPR established an ADI of 0–0.004mg/kgbw as paraquat ion (equal to 0–0.006mg/kgbw as the dichloride).

Table of Contents
Explanation.................................................................................................... 203 Evaluation for acceptable daily intake.......................................................... 204 Biochemical aspects ................................................................................ 204 Absorption, distribution and excretion .............................................. 204 Biotransformation .............................................................................. 209 Toxicological studies ............................................................................... 210 Acute toxicity ..................................................................................... 210 Dermal irritation........................................................................... 210 Ocular irritation ............................................................................ 210 Dermal sensitization ..................................................................... 212 Short-term studies of toxicity ............................................................ 212 Oral administration....................................................................... 212 Dermal application ....................................................................... 216 Exposure by inhalation................................................................. 217 Long-term studies of toxicity and carcinogenicity ............................ 218 Genotoxicity ....................................................................................... 226 Reproductive toxicity ......................................................................... 227 Multigeneration studies ................................................................ 227 Developmental toxicity................................................................. 237 Special studies.................................................................................... 240 Mechanistic studies ...................................................................... 240 Liver toxicity ................................................................................ 242 Kidney toxicity ............................................................................. 243 Neurotoxicology ........................................................................... 243 Possible neurotoxic interactions ................................................... 246 Experimental therapies ................................................................. 247 Poisoning of animals .................................................................... 247 Observations in humans .......................................................................... 247 Poisoning incidents ............................................................................ 247 Epidemiological studies ..................................................................... 250 Studies in human volunteers.............................................................. 251 Comments...................................................................................................... 251 Toxicological evaluation................................................................................ 255 References ..................................................................................................... 256

 

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