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World Health Organization Publication : Year 2005 ; Issue 9241530642 - in English: Concise International Chemical Assessment Document 64

By World Health Organization

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Book Id: WPLBN0000195683
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005
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Title: World Health Organization Publication : Year 2005 ; Issue 9241530642 - in English: Concise International Chemical Assessment Document 64  
Author: World Health Organization
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Organization, W. H. (n.d.). World Health Organization Publication : Year 2005 ; Issue 9241530642 - in English. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
Concise International Chemical Assessment Documents (CICADs) are published by the International Programme on Chemical Safety (IPCS) — a cooperative programme of the World Health Organization (WHO), the International Labour Organization (ILO), and the United Nations Environment Programme (UNEP). CICADs have been developed from the Environmental Health Criteria documents (EHCs), more than 200 of which have been published since 1976 as authoritative documents on the risk assessment of chemicals. International Chemical Safety Cards on the relevant chemical(s) are attached at the end of the CICAD, to provide the reader with concise information on the protection of human health and on emergency action. They are produced in a separate peer-reviewed procedure at IPCS. They may be complemented by information from IPCS Poison Information Monographs (PIM), similarly produced separately from the CICAD process.

Table of Contents
TABLE OF CONTENTS FOREWORD..................................................................................................................................................1 1. EXECUTIVE SUMMARY............................................................................................................................4 2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES ..........................................................................5 3. ANALYTICAL METHODS..........................................................................................................................6 3.1 Environmental monitoring....................................................................................................................6 3.2 Biological monitoring..........................................................................................................................7 4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE ..............................................................7 5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION ............................... 8 5.1 Transport and distribution................................................................................................................... 8 5.2 Biotransformation ............................................................................................................................... 9 5.3 Bioaccumulation ................................................................................................................................. 9 6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE......................................................................10 6.1 Environmental levels ..........................................................................................................................10 6.2 Human exposure ................................................................................................................................10 7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS.....................................................................................................................................................10 8. EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS .....................................13 8.1 Single exposure..................................................................................................................................13 8.1.1 n-Butyl acetate .........................................................................................................................13 8.1.2 Isobutyl acetate ........................................................................................................................15 8.1.3 sec-Butyl acetate ......................................................................................................................15 8.1.4 tert-Butyl acetate......................................................................................................................15 8.2 Irritation and sensitization ..................................................................................................................16 8.2.1 n-Butyl acetate .........................................................................................................................16 8.2.2 Isobutyl acetate ........................................................................................................................17 8.2.3 sec-Butyl acetate ......................................................................................................................17 8.2.4 tert-Butyl acetate......................................................................................................................17 8.3 Short-term exposure...........................................................................................................................18 8.3.1 n-B

 

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