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World Health Organization : Year 2001 ; Communicable Diseases and Emerging Infectious Diseases ; Roll Back Malaria, No. 2001.35: Antimalarial Drug Combination Therapy Report of a World Health Organization Technical Consultation

By M. Geyer

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Book Id: WPLBN0000197408
Format Type: PDF eBook
File Size: 1.3 MB
Reproduction Date: 2005
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Title: World Health Organization : Year 2001 ; Communicable Diseases and Emerging Infectious Diseases ; Roll Back Malaria, No. 2001.35: Antimalarial Drug Combination Therapy Report of a World Health Organization Technical Consultation  
Author: M. Geyer
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
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Publisher: World Health Organization

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Geyer, M. (n.d.). World Health Organization : Year 2001 ; Communicable Diseases and Emerging Infectious Diseases ; Roll Back Malaria, No. 2001.35. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
INTRODUCTION A WHO Technical Consultation on Antimalarial Combination Therapy was held in Geneva, Switzerland on 4 and 5 April 2001. Participants reflected a wide range of expertise in the development and use of antimalarial drugs (Annex 1). Early diagnosis and prompt treatment is one of the principal technical components of the global strategy to control malaria (1). The effectiveness of this intervention is highly dependent on antimalarial drugs, which should not only be safe and effective, but also available, affordable and acceptable to the population at risk. The rational use of an effective antimalarial drug not only reduces the risk of severe disease and death and shortens the duration of the illness, but also contributes to slowing down the development of the parasite’s resistance to antimalarial drugs. The emergence and rapid spread of P. falciparum resistance to commonly used antimalarial drugs poses a serious challenge to the effectiveness of early diagnosis and prompt treatment as a priority strategy within current malaria control efforts (2-4).

Table of Contents
CONTENTS Introduction ............................................................................................5 1. Combination therapy in the context of treatment policy ...........................6 1.1 Purpose of drug policy........................................................................6 1.2 Combination therapy with antimalarial drugs........................................7 Rationale for the use of combination therapy in Africa..................................7 2. Antimalarial therapy combination drugs..................................................9 2.1 Non-artemisinin based combinations ...................................................9 Chloroquine plus sulfadoxine-pyrimethamine...............................................9 Amodiaquine plus sulfadoxine-pyrimethamine ...........................................10 Atovaquone-proguanil (MalaroneTM)..................................................................................................................................................................................................11 Mefloquine-sulfadoxine-pyrimethamine (FansimefTM)............................................................................................................................................11 Quinine plus tetracycline or doxycycline.....................................................................................................................................................................................12 2.2 Artemisinin-based combinations..............................................................................................................................................................................................................12 Artesunate plus chloroquine............................................................................................................................................................................................................................13 Artesunate plus amodiaquine.........................................................................................................................................................................................................................14 Artesunate plus sulfadoxine-pyrimethamine ........................................................................................................................................................................14 Artesunate plus mefloquine..............................................................................................................................................................................................................................14 Artemether-lumefantrine (CoartemTM , RiametTM )........................................................................................................................................................15 2.3 Combinations in the pipeline.......................................................................................................................................................................................................................16 Piperaquine-dihydroartemisinin-trimethoprim (ArtecomTM ) and ArtecomTM plus primaquine (CV8TM)...................................................................................................................................................................................................................................................16 Pyronaridine plus artesunate...........................................................................................................................................................................................................................17 Naphthoquine plus dihydroartemisinin.............................................................................................................................

 

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