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Response to Subject Matter Expert Review Comments on Niosh-Irep

By Department of Health and Human Services

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Book Id: WPLBN0000199928
Format Type: PDF eBook
File Size: 0.9 MB
Reproduction Date: 2005

Title: Response to Subject Matter Expert Review Comments on Niosh-Irep  
Author: Department of Health and Human Services
Volume:
Language: English
Subject: Health., Medical research, Medical reports
Collections: Medical Library Collection
Historic
Publication Date:
Publisher: Centers for Disease Control and Prevention

Citation

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Health And Human Services, D. O. (n.d.). Response to Subject Matter Expert Review Comments on Niosh-Irep. Retrieved from http://hawaiilibrary.net/


Excerpt
Comments: Several reviewers (R. Shore, D. Stram, R. Hornung) questioned whether this practice would be more likely to result in a claim award for less-radiogenic cancers, which presumably have higher error estimates about the ERRlSv, than for cancers acknowledged to be strongly associated with cancer. D. Stram recommended the use ofrandom effects models to reduce the tendency for rarer cancers to be conlpensated. Response: The relevance of these comments depends on several factors, including the method by which radiogenicity is defined, and the intent of the EEOICPA in addressing the role of uncertainty in awarding claims. While the latter issue results from a mandate of congress, the former issue may be addressed explicitly, by considering the uncertainties in risk coefficients from the Japanese A-bomb cohort for various cancers. The radiogenicity of many cancers has been classified (somewhat informally) by Boice et al. (1996), into four groupings, based on the totality of the epidemiologic evidence regarding their association with ionizing radiation exposure. The four cancer groupings are: 1. Cancers frequently associated with radiation with authoritative risk estimates Leukemia (except CLL), thyroid, female breast 2. Cancers occasionally associated with radiation with valid risk estimates Lung, stomach, colon, esophagus, bladder, ovary, multiple myeloma 3. Cancers rarely associated with radiation with uncertain risk estimates Brain and nervous system, kidney, liver, salivary glands, non-Hodgkin's lymphoma, skin, rectum, uterus, hone, connective tissues 4. Cancers never or sporadically associated with radiation with no risk estimates Chronic lymphocytic leukemia, pancreas, Hodgkin's disease, prostate, testis, cervix, retinoblastoma, Wilms' tumor, and others of embryonic origin, muscles, tendons, and synovial membranes ofjoints...

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