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European Occupational Health Series : Year 1993; Prevention in Primary Care, Global Programme on Aids, Report No. 059 (A): Coordinated Care Services for People Living with HIV/AIDS

By Bart Eijrond

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Book Id: WPLBN0000233516
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title: European Occupational Health Series : Year 1993; Prevention in Primary Care, Global Programme on Aids, Report No. 059 (A): Coordinated Care Services for People Living with HIV/AIDS  
Author: Bart Eijrond
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Eijrond, B. (n.d.). European Occupational Health Series : Year 1993; Prevention in Primary Care, Global Programme on Aids, Report No. 059 (A). Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
A period of drrect contact wirlr a concentration of 20 ~ g / r nolr less of either famorine (1-jp-rhlorophenoxyr~~~rI~ylJ-3,4-d~lrydroisoguinhoyldironceh loride) or memotine fl-lpnrefhoxyphetioxv, i1~thy/j-3.4-dih~droi~oquinoIhiynde~ ochloride) i~mctrvatesm yxoviruses andparamyxoviruses. This rrctirrt? has beer, confirmed in organ culrore prepared from dog trachea and infected with a11 rr~ffucrr.-aA 2 virus. Consistent protection ofmice rnj2rted intranasally with influenza A/PR/8 has not been obrained. Other viruses causing respiratory disease in man, in particular some rhinoviruses, are srrsceplible during replicarion to the action of these compos~~rlsB. oth compounds are oflow toxicity and well tolerated b.v man. Trials in man have embruced choilenge, prophylactic and tl~eraperrtics tirdies with both oral and local administration. Cl~nllunpe studies with influenza A2 and B vivrises have demonstrated that witlz sonre st,-ai~rs there is in the drug-treated groups u reduction in the incidence of evidence of infection. sometinies significantly, and also a reduction of clinical symptoms, rhe efect towards inflrrenzn B virus being the greater. Nasal instillalion of famotrne reduced the incidence of clinical s.vmptoms only followi~rg challenge with infienra B virrrs nnd rhinovirus 1-vpe 2. Orol propl~ylactic trials have been inconclusive, althoriglr the nasal inrrillarion of fa,rrorn!r did reduce somewi~at the incidence of symptoms in rr small ourbrr.ok o/ i,rflne,r;o A2,Hojrg Kong/68. The number of therapeutic trials has been too few and too small to ~~vnlrmrceo nclusively the role of fltese agents in therapy of acrrfe respiratory illness.

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