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Bulletin of the World Health Organization : 1968; Volume 39, Number 5, Year 1968, Pages 781-789: Deterioration of Cycloserine in the Tropics

By K. V. Nageswara Rao

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Book Id: WPLBN0000234878
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title: Bulletin of the World Health Organization : 1968; Volume 39, Number 5, Year 1968, Pages 781-789: Deterioration of Cycloserine in the Tropics  
Author: K. V. Nageswara Rao
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Nageswara Rao, K. V. (n.d.). Bulletin of the World Health Organization : 1968; Volume 39, Number 5, Year 1968, Pages 781-789. Retrieved from http://hawaiilibrary.net/


Description
Medical Reference Publication

Excerpt
A variety of meningococcal vaccines have been prepared and used in the past in attempts to control outbreaks of cerebrospinal meningitis (CSM), the first trial of such a vaccine in Africa having been carried out in the Sudan as long ago as 1915 (1). The results of such trials were generally poor or inconclusive, although in certain instances protection appeared to follow inoculation (2). More recently, specific immunization against meniugococcal infec- tions was recommended as a first priority in a research programme submitted to the World Health Organization (Lapeyssonnie, unpublished report, 1960). In 1964, therefore, a whole-cell vaccine was prepared by the Institut Mkrieux, Lyon, France, and in 1965 an enzyme-lysed vaccine was prepared by the Laboratory of Hygiene in the Department of National Health and Welfare of Canada (3). Both were monospecific to group A, hut a trial in Upper Volta in 196668 failed to assess their value (4). With improved understanding of the immunological properties of meningococcal antigens and with better techniaues for their isolation and uurificatlon (5). the polyosides (i.e., the polysaccharides) of the outer layer of d\reisseria vienilrgitidis were considered. by analog). wirh the pneumococcal polyosides. as potentially suitable substances for immunization. 'Memngococcal polyoside C vaccine, first tried in the US Army, conferred protection (6), and it is possible that the present decline of meningococcal memugitis in the military population in the USA is related to the application of this vaccine to the recruits (7).

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