World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Computational Biology : a Survey of Genomic Properties for the Detection of Regulatory Polymorphisms, Volume 3

By Pilpel, Yitzhak

Click here to view

Book Id: WPLBN0003924228
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Computational Biology : a Survey of Genomic Properties for the Detection of Regulatory Polymorphisms, Volume 3  
Author: Pilpel, Yitzhak
Volume: Volume 3
Language: English
Subject: Journals, Science, Computational Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Computational Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Pilpel, Y. (n.d.). Plos Computational Biology : a Survey of Genomic Properties for the Detection of Regulatory Polymorphisms, Volume 3. Retrieved from http://hawaiilibrary.net/


Description
Description : Advances in the computational identification of functional noncoding polymorphisms will aid in cataloging novel determinants of health and identifying genetic variants that explain human evolution. To date, however, the development and evaluation of such techniques has been limited by the availability of known regulatory polymorphisms. We have attempted to address this by assembling, from the literature, a computationally tractable set of regulatory polymorphisms within the ORegAnno database (http:/www.oreganno.org). We have further used 104 regulatory single-nucleotide polymorphisms from this set and 951 polymorphisms of unknown function, from 2-kb and 152-bp noncoding upstream regions of genes, to investigate the discriminatory potential of 23 properties related to gene regulation and population genetics. Among the most important properties detected in this region are distance to transcription start site, local repetitive content, sequence conservation, minor and derived allele frequencies, and presence of a CpG island. We further used the entire set of properties to evaluate their collective performance in detecting regulatory polymorphisms. Using a 10-fold cross-validation approach, we were able to achieve a sensitivity and specificity of 0.82 and 0.71, respectively, and we show that this performance is strongly influenced by the distance to the transcription start site.

 

Click To View

Additional Books


  • Plos Computational Biology : Non-linear ... (by )
  • Plos Computational Biology : Critical Dy... (by )
  • Plos Computational Biology : Recombinati... (by )
  • Plos Computational Biology : Risk-sensit... (by )
  • Plos Computational Biology : Beadarray E... (by )
  • Plos Computational Biology : an Entropic... (by )
  • Plos Computational Biology : Predicting ... (by )
  • Plos Computational Biology : Increased V... (by )
  • Plos Computational Biology : Significanc... (by )
  • Plos Computational Biology : Nitric Oxid... (by )
  • Plos Computational Biology : Ten Simple ... (by )
  • Plos Computational Biology : Chemically ... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.