World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Computational Biology : Bang-bang Control of Feeding ; Role of Hypothalamic and Satiety Signals, Volume 3

By Friston, Karl, J.

Click here to view

Book Id: WPLBN0003924243
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Computational Biology : Bang-bang Control of Feeding ; Role of Hypothalamic and Satiety Signals, Volume 3  
Author: Friston, Karl, J.
Volume: Volume 3
Language: English
Subject: Journals, Science, Computational Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Computational Biology
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Friston, K. J. (n.d.). Plos Computational Biology : Bang-bang Control of Feeding ; Role of Hypothalamic and Satiety Signals, Volume 3. Retrieved from http://hawaiilibrary.net/


Description
Description : Rats, people, and many other omnivores eat in meals rather than continuously. We show by experimental test that eating in meals is regulated by a simple bang-bang control system, an idea foreshadowed by Le Magnen and many others, shown by us to account for a wide range of behavioral data, but never explicitly tested or tied to neurophysiological facts. The hypothesis is simply that the tendency to eat rises with time at a rate determined by satiety signals. When these signals fall below a set point, eating begins, in on–off fashion. The delayed sequelae of eating increment the satiety signals, which eventually turn eating off. Thus, under free conditions, the organism eats in bouts separated by noneating activities. We report an experiment with rats to test novel predictions about meal patterns that are not explained by existing homeostatic approaches. Access to food was systematically but unpredictably interrupted just as the animal tried to start a new meal. A simple bang-bang model fits the resulting meal-pattern data well, and its elements can be identified with neurophysiological processes. Hypothalamic inputs can provide the set point for longer-term regulation carried out by a comparator in the hindbrain. Delayed gustatory and gastrointestinal aftereffects of eating act via the nucleus of the solitary tract and other hindbrain regions as neural feedback governing short-term regulation. In this way, the model forges real links between a functioning feedback mechanism, neuro–hormonal data, and both short-term (meals) and long-term (eating-rate regulation) behavioral data.

 

Click To View

Additional Books


  • Plos Computational Biology : Filament De... (by )
  • Plos Computational Biology : Effect of P... (by )
  • Plos Computational Biology : from Morpho... (by )
  • Plos Computational Biology : Identificat... (by )
  • Plos Computational Biology : Evolution a... (by )
  • Plos Computational Biology : Comparative... (by )
  • Plos Computational Biology : Neural Codi... (by )
  • Plos Computational Biology : Expanding t... (by )
  • Plos Computational Biology : Optimal Com... (by )
  • Plos Computational Biology : Association... (by )
  • Plos Computational Biology : Time to Org... (by )
  • Plos Computational Biology : Evolutionar... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.