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Plos Computational Biology : Efficiency and Cost of Economical Brain Functional Networks, Volume 3

By Friston, Karl, J.

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Book Id: WPLBN0003924297
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Computational Biology : Efficiency and Cost of Economical Brain Functional Networks, Volume 3  
Author: Friston, Karl, J.
Volume: Volume 3
Language: English
Subject: Journals, Science, Computational Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Computational Biology
Publication Date:
Publisher: Plos


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Friston, K. J. (n.d.). Plos Computational Biology : Efficiency and Cost of Economical Brain Functional Networks, Volume 3. Retrieved from

Description : Brain anatomical networks are sparse, complex, and have economical small-world properties. We investigated the efficiency and cost of human brain functional networks measured using functional magnetic resonance imaging (fMRI) in a factorial design : two groups of healthy old (N¼11: mean age¼66.5 years) and healthy young (N¼15: mean age¼ 24.7 years) volunteers were each scanned twice in a no-task or ‘‘resting’’ state following placebo or a single dose of a dopamine receptor antagonist (sulpiride 400 mg). Functional connectivity between 90 cortical and subcortical regions was estimated by wavelet correlation analysis, in the frequency interval 0.06–0.11 Hz, and thresholded to construct undirected graphs. These brain functional networks were small-world and economical in the sense of providing high global and local efficiency of parallel information processing for low connection cost. Efficiency was reduced disproportionately to cost in older people, and the detrimental effects of age on efficiency were localised to frontal and temporal cortical and subcortical regions. Dopamine antagonism also impaired global and local efficiency of the network, but this effect was differentially localised and did not interact with the effect of age. Brain functional networks have economical small-world properties—supporting efficient parallel information transfer at relatively low cost—which are differently impaired by normal aging and pharmacological blockade of dopamine transmission.


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