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Plos Computational Biology : Regulatory Control and the Costs and Benefits of Biochemical Noise, Volume 4

By Regev, Aviv

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Book Id: WPLBN0003925756
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Computational Biology : Regulatory Control and the Costs and Benefits of Biochemical Noise, Volume 4  
Author: Regev, Aviv
Volume: Volume 4
Language: English
Subject: Journals, Science, Computational Biology
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Computational Biology
Publication Date:
Publisher: Plos


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Regev, A. (n.d.). Plos Computational Biology : Regulatory Control and the Costs and Benefits of Biochemical Noise, Volume 4. Retrieved from

Description : Experiments in recent years have vividly demonstrated that gene expression can be highly stochastic. How protein concentration fluctuations affect the growth rate of a population of cells is, however, a wide-open question. We present a mathematical model that makes it possible to quantify the effect of protein concentration fluctuations on the growth rate of a population of genetically identical cells. The model predicts that the population’s growth rate depends on how the growth rate of a single cell varies with protein concentration, the variance of the protein concentration fluctuations, and the correlation time of these fluctuations. The model also predicts that when the average concentration of a protein is close to the value that maximizes the growth rate, fluctuations in its concentration always reduce the growth rate. However, when the average protein concentration deviates sufficiently from the optimal level, fluctuations can enhance the growth rate of the population, even when the growth rate of a cell depends linearly on the protein concentration. The model also shows that the ensemble or population average of a quantity, such as the average protein expression level or its variance, is in general not equal to its time average as obtained from tracing a single cell and its descendants. We apply our model to perform a cost-benefit analysis of gene regulatory control. Our analysis predicts that the optimal expression level of a gene regulatory protein is determined by the trade-off between the cost of synthesizing the regulatory protein and the benefit of minimizing the fluctuations in the expression of its target gene. We discuss possible experiments that could test our predictions.


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