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Plos Genetics : Novel Association of Abo Histo-blood Group Antigen with Soluble Icam-1 ; Results of a Genome-wide Association Study of 6,578 Women, Volume 4

By Gibson, Greg

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Book Id: WPLBN0003926074
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Novel Association of Abo Histo-blood Group Antigen with Soluble Icam-1 ; Results of a Genome-wide Association Study of 6,578 Women, Volume 4  
Author: Gibson, Greg
Volume: Volume 4
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
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Publisher: Plos

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Gibson, G. (n.d.). Plos Genetics : Novel Association of Abo Histo-blood Group Antigen with Soluble Icam-1 ; Results of a Genome-wide Association Study of 6,578 Women, Volume 4. Retrieved from http://hawaiilibrary.net/


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Description : While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women’s Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are nonredundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P,561028), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1610229) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.

 

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