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Plos One : Met is Required for the Maximal Action of 20- Hydroxyecdysone During Bombyxmetamorphosis, Volume 7

By Picard, Didier

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Book Id: WPLBN0003940554
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Met is Required for the Maximal Action of 20- Hydroxyecdysone During Bombyxmetamorphosis, Volume 7  
Author: Picard, Didier
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Picard, D. (n.d.). Plos One : Met is Required for the Maximal Action of 20- Hydroxyecdysone During Bombyxmetamorphosis, Volume 7. Retrieved from http://hawaiilibrary.net/


Description
Description : Little is known about how the putative juvenile hormone (JH) receptor, the bHLH-PAS transcription factor MET, is involved in 20-hydroxyecdysone (20E: the molting hormone) action. Here we report that two MET proteins found in the silkworm, Bombyx mori, participate in 20E signal transduction. Met is 20E responsive and its expression peaks during molting and pupation, when the 20E titer is high. As found with results from RNAi knockdown of EcR-USP (the ecdysone receptor genes), RNAi knockdown of Met at the early wandering stage disrupts the 20E-triggered transcriptional cascade, preventing tissue remodeling (including autophagy, apoptosis and destruction of larval tissues and generation of adult structures) and causing lethality during the larval-pupal transition. MET physically interacts with EcR-USP. Moreover, MET, EcR-USP and the 20E-response element (EcRE) form a protein-DNA complex, implying that MET might modulate 20E-induced gene transcription by interacting with EcR-USP. In conclusion, the 20E induction of MET is required for the maximal action of 20E during Bombyx metamorphosis.

 

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