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Plos One : Innexin 3, a New Gene Required for Dorsal Closure in Drosophila Embryo, Volume 8

By Fanning, Alan S.

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Book Id: WPLBN0003950722
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Innexin 3, a New Gene Required for Dorsal Closure in Drosophila Embryo, Volume 8  
Author: Fanning, Alan S.
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Fanning, A. S. (n.d.). Plos One : Innexin 3, a New Gene Required for Dorsal Closure in Drosophila Embryo, Volume 8. Retrieved from http://hawaiilibrary.net/


Description
Description : Here, we show that Innexin 1, 2 and 3, are present in the ectoderm but also in the amnioserosa in plaques consistent with gap junctions. However, only the loss of Inx3 leads to dorsal closure defects that are completely rescued by overexpression of inx3::GFP in the whole embryo. Loss of Inx3 leads to the destabilisation of Inx1, Inx2 and DEcadherin at the plasma membrane, suggesting that these four proteins form a complex. Accordingly, in addition to the known interaction of Inx2 with DE-cadherin, we show that Inx3 can bind to DE-cadherin. Furthermore, Inx3-GFP overexpression recruits DE-cadherin from its wildtype plasma membrane domain to typical Innexin plaques, strengthening the notion that they form a complex. Finally, we show that Inx3 stability is directly dependent on tissue tension. Taken together, we propose that Inx3 is a critical factor for dorsal closure and that it mediates the stability of Inx1, 2 and DEcadherin by forming a complex.

 

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